foxo4 gene FOXO4 - Humanin foxO4 Unraveling the Multifaceted Role of the FOXO4 Gene in Cellular Health and Disease

FOXO3 The foxo4 gene, encoding the Forkhead box O4 (FOXO4) protein, plays a pivotal role in maintaining cellular homeostasis and is implicated in a variety of biological processes, from cell survival and metabolism to its involvement in the development of diseases such as cancer and age-related conditionsGenAge entry for FOXO4 (Homo sapiens). As a member of the FOXO family transcription factors, FOXO4 acts as a critical regulator by integrating stress-related signals and influencing the expression of numerous downstream genesSymbol report for FOXO4. Understanding the intricacies of the foxo4 gene is crucial for comprehending its broad impact on human health.Foxo4 (forkhead box O4) | Gene Report

FOXO4 is a protein-coding gene identified in humans and other species, including mice and rats, highlighting its evolutionary conservation and fundamental biological importanceHuman Gene FOXO4 (ENST00000374259.8) from .... The Human Genome Organisation (HUGO) Gene Nomenclature Committee (HGNC) has approved FOXO4 as the official symbol for this geneGene:Foxo4ENSMUSG00000042903 . Description. forkhead box O4 [Source:MGI Symbol;Acc:MGI:1891915].GeneSynonyms. Afxh,Foxo4, Mllt7, afx. Location. Chromosome .... Its genomic coordinates are located at Xq13.1 on the human X chromosome, with a notable alternative name being AFX1, distinguishing it from other FOXO genes. This gene has several known transcripts and numerous orthologues and paralogues, indicating a complex regulatory network and functional redundancy within the FOXO family.

The FOXO4 gene is involved in a diverse array of cellular pathways.GXD's primary emphasis is on endogenousgeneexpression during development. Click on grid cells to view annotations. Blue cells = expressed in wild-type. ... ( ... It is recognized for its role in the insulin signaling pathway, where it binds to insulin-response elements (IREs) and can activate the transcription of specific genes. This direct involvement underscores its significance in metabolic regulation. Furthermore, FOXO4 acts upstream and is involved in intracellular oxygen homeostasis and the organism's response to hypoxia. Studies have indicated that low expression of the FoxO4 gene may contribute to certain physiological phenomena, suggesting a direct correlation between its functional levels and cellular well-beingSpatiotemporal expression of foxo4, foxo6a, and foxo6b in the ....

Emerging research highlights the significant involvement of the FOXO4 gene in the context of cancer.FOXO4 Gene - Ma'ayan Lab – Computational Systems Biology It has been observed that a loss or dysregulation of FOXO4 expression is associated with the development and progression of various cancers, including colorectal cancer and sarcoma, such as bone sarcoma. FOXO4 may function as a tumor suppressor in certain contexts. Conversely, under conditions of high oxidative stress, activated FOXO4 can induce the expression of pro-apoptotic genes, thereby promoting the elimination of damaged cells, a critical mechanism for preventing tumor formation. The RAS pathway related proteins are also linked to FOXO4 function, indicating its integration into oncogenic signaling networks.Current perspective on the regulation of FOXO4 and its role in disease ...

Beyond cancer, the FOXO4 gene has garnered attention for its potential relevance to the human ageing process.FOXO4 General Information FOXO4-DRI, a specific peptide derived from FOXO4, has shown promise in alleviating age-related testosterone secretion insufficiency. This suggests that modulating FOXO4 activity or utilizing FOXO4 peptides could offer therapeutic avenues for conditions associated with aging. The GenAge entry for FOXO4 classifies it as having potential relevance to human aging, based on evidence directly linking the gene product to aging in various organismsFOXO4 - an overview.

The foxo4 gene has also been investigated in other species, providing valuable insights into its conserved functions. In zebrafish, deletion of the foxO4 gene has been shown to increase hypoxia tolerance, and genes regulating mitochondrial respiratory function exhibit low expression in these foxO4-deficient zebrafish. This further emphasizes the role of FOXO4 in cellular respiration and adaptation to environmental stress.FOXO4(AFX1, MLLT7) · Cancer-relatedgenes. Disease relatedgenes. RAS pathway related proteins In mice, the foxo4 gene is expressed in various tissues during development, with its spatiotemporal expression being a subject of detailed study in developmental biology.

The diversity of FOXO4's functions is reflected in its involvement in multiple cellular pathways, including IL-9 Signaling. The regulation of FOXO4 is a complex process, influenced by various cellular signals and post-translational modifications. This intricate control allows FOXO4 to orchestrate responses crucial for cell survival, proliferation, differentiation, and apoptosis. Dysregulated expressions of FOXO genes, including FOXO4, have been identified in numerous tumors and genetic disorders, underscoring their broad impact.

In summary, the foxo4 gene is a fundamental component of cellular regulation with far-reaching implications. Its roles as a transcription factor involved in stress response, metabolic control, cancer-related gene expression, and potentially aging processes make it a compelling subject of ongoing research. Further exploration of FOXO4 and its related genes, including FOXO3, and interventions like FOXO4-DRI, holds promise for advancing our understanding of health and disease, and for developing novel therapeutic strategiesFoxo4 - Forkhead box protein O4 - Mus musculus (Mouse). The study of this genetic element continues to reveal its profound influence on biological systems.Foxo4 (forkhead box O4) | Gene Report